Helicobacter pylori Infection and Migraine

Objective: To determine whether Helicobacter pylori (H. pylori) is associated with migraine headache. Design: Case-control study. Settings: Local tertiary Hospitals in Cairo, Egypt and in Hafer Albaten, Saudi Arabia. Participants: A total of 70 patients with migraine who were 7 to 17 years old and who fulfilled the International Headache Society criteria for migraine and a total of 50 controls without migraine who were matched by the country of origin, age, sex, ethnicity, and socioeconomic status to the 70 migraine cases. Main outcome Measures: Antibody levels to H. pylori (IgG) and H. pylori stool antigens were compared between the two groups. Results: Significant association was found between H. pylori and migraine and of the total of 70 migraineur cases, 55.7% were positive for H. pylori stool antigen testing compared to 20% in control group (P value = 0.0002). Joint pain was reported in 44.3% and 18.0% of cases and controls respectively (P value = 0.0034). Conclusion: H. pylori is associated with migraine without aura and may be a causative factor. Moreover, H. pylori may induce joint pain in the migraineur patients